
Ameretat Neurogenesis Supplement
$45.00
Ameretat Neurogenesis supplement is formulated with extracts of Espand, an ancestral plant that has been used by our Iranian ancestors for thousands of years in rituals. Magi’s team of PhD scientists and ethnopharmacologists created Ameretat Neurogenesis Supplement to contain a sub-perceptive neuroprotective microdose of Espand extracts. This extract formulation is a natural source of beta-carbolines that are unique neuromodulators promoting a normal and healthy response to cerebral inflammation and release of brain growth factors.
“An ounce of prevention is worth a pound of cure.” – Benjamin Franklin
- Ameretat Neurogenesis is formulated to contain a precise sub-perceptive microdose of select beta-carbolines to support neuroprotection and neurogenesis.
- Ameretat Neurogenesis is all-natural, non-habit-forming, and improves over time.
- Improve brain function today, for tomorrow.
Product Description
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

Instructions
- Take one capsule 15 minutes before sleeping and at least 3 hours after eating, or take one capsule upon waking on an empty stomach and wait at least 2 hours before eating.
- Do not exceed the recommended daily dose. Do not take it if you are pregnant or nursing. Consult with your physician prior to use if you have high blood pressure or a medical condition or if you take any prescription medications (including but not limited to MAO inhibitors and antidepressants).
- Store in a cool, dry place. Keep out of reach of children and pets.
FAQ
How will I feel after taking Neurogenesis Supplement?
- Ameretat Neurogenesis nootropic is a sub-perceptive (microdosing) neuroprotective formulation that will not cause you to feel physiological effects. Over time, people report feeling sharper and more focused after regular supplementation.
Should I take Ameretat Neurogenesis Supplement every day?
- The neuromodulatory effects of Ameretat Neurogenesis supplement are immediate but sub-perceptive, non-sedative, and not habit-forming. We designed Ameretat Neurogenesis so that you can take it every morning or evening without becoming dependent.
- Although not habit-forming, we recommend incorporating Ameretat Neurogenesis into either a consistent waking or sleeping ritual.
Is Magi Ameretat Neurogenesis Supplement safe?
- Ameretat Neurogenesis is safe when taken as directed at the recommended dosage.
- Ameretat Neurogenesis contains Defense(R), a purified plant extract of Espand that is formulated to contain a precise microdose of beta-Carbolines. In addition to their anti-inflammatory and neuroprotective properties, beta-Carbolines also function as monoamine oxidase inhibitors (MAOIs) [1] that can cause an increase in blood pressure when consuming foods containing tyramine [2].
- For this reason, the Ameretat Neurogenesis supplement should only be taken on an empty stomach, at least 3 hours after eating or 2 hours before eating. It’s best to avoid consuming tyramine-rich foods altogether when taking the Ameretat Neurogenesis supplement.
How does it work?
- Ameretat Neurogenesis Supplement contains Defense®, a precise microdose formulation of Espand-derived beta-Carbolines that, while sub-perceptive, begins to affect the central nervous system within 20 minutes of being ingested. The compounds in Defense® have been shown to:
- Inhibit neurotoxins [3] and provide neuroprotective antioxidant effects [4]
- Inhibit tumor cells [5] and promote the growth of anti-tumor cytokines [6]
- Inhibit the expression of the DYRK1a gene, which is attributed to neurodegenerative symptoms
- Inhibit inflammatory signaling and the growth of inflammatory prostaglandins [7]
- Promote neurogenesis in adults by increasing BDNF and hNPC levels
- Modulate neuroreceptors such as serotonin, dopamine, acetylcholine, histamine, and imidazoline that are involved in perception and consciousness [8]
Ancestral Philosophy
Espand – Holy Plant Wisdom
Ameretat is the divine concept of immortality pursued ritually by the Zoroastrians of Ancient Iran (Persia) through spiritual inner journey practices. Espand, also known as Wild Rue or Peganum Harmala, is the fundamental ancestral plant consumed and burned as incense in these ancestral traditions and is the key ingredient in Ameretat Neurogenesis Supplement.
Espand, also known as Wild Rue or Peganum Harmala. Espand is an abundant source of beta-carbolines [9], a class of naturally occurring organic compounds with psychoactive and neuroprotective properties [10]. Beta-carbolines are found naturally in a few plants, including Espand (P. Harmala) and Yage (Banisteriopsis Caapi), the ancestral Amazonian plant that is the main ingredient in the psychedelic brew Ayahuasca [11]. Thanks to modern science, we now understand the neurochemistry behind what our ancestors discovered thousands of years ago.
Pharmaceutical Science
Beta-Carbolines – Ancestral Secret to Neurological Health
Beta-carbolines such as harmine [12] are unique neuromodulators that have been shown to exhibit anti-inflammatory activity in neurons [13] and promote neurogenesis by increasing levels of brain-derived neurotrophic factor (BDNF) [14] and human neural progenitor cells (hNPC) [15]. They are also potent inhibitors of DYRK genes, particularly DYRK1a [16], the protein kinase implicated in the pathology of numerous neurodegenerative disorders [17].
Beta-carbolines also interact with the sleep cycle via the pineal gland, the part of the brain that regulates the body’s circadian rhythm. The pineal gland regulates the sleep cycle via synthesis of melatonin from serotonin (the “happiness hormone”) [18], and is also believed to produce both beta-carbolines and the psychedelic compound DMT (the “spirit molecule”) via alternate pathways [19].
References
- [1] Mckenna, Dennis J., et al. “Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of Ayahuasca.” Journal of Ethnopharmacology, vol. 10, no. 2, Apr 1984, pp 195-223. https://doi.org/10.1016/0378-8741(84)90003-5
- [2] McCabe, Beverly J. “Dietary tyramine and other pressor amines in MAOI regimens: A review.” Journal of the American Dietetic Association, vol.86, no. 8, Aug 1986, pp. 1059-1064. https://doi.org/10.1016/S0002-8223(21)04074-8
- [3] Herraiz, Tomás, and Hugo Guillén. “Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.” Food and Chemical Toxicology, 2011 Aug;49(8):1773-81. doi: 10.1016/j.fct.2011.04.026.
- [4] Samoylenko, Volodymyr, et al. “Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson’s disease.” Journal of Ethnopharmacology, vol. 127, no. 2, Feb 2010, pp. 357-367. https://doi.org/10.1016/j.jep.2009.10.030
- [5] Bikadar, SM, et al. “Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice.” Pakistan Journal of Biological Sciences, 01 Dec 2013, 16(23):1687-1697. DOI: 10.3923/pjbs.2013.1687.1697
- [6] Hamsa, T.P., and Girija Kuttan. “Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro.” European Journal of Pharmacology, 2010 Dec 15;649(1-3):64-73. doi: 10.1016/j.ejphar.2010.09.010.
- [7] Moloudizargari, Milad, et al. “Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids.” Pharmacognosy Reviews, 2013 Jul-Dec; 7(14): 199–212. doi: 10.4103/0973-7847.120524
- [8] Airaksinen, MM, and Kari I. “Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism.” Medical Biology. 1981 Feb;59(1):21-34. PMID: 7022042.
- [9] Frost, Danielle, et al. “β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer’s Disease-Related Sites.” PLoS ONE 6(5): e19264, May 2011. https://doi.org/10.1371/journal.pone.0019264
- [10] Dennis J McKenna,“Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.” Pharmacology & Therapeutics, Volume 102, Issue 2, 2004, pp. 111-129. https://doi.org/10.1016/j.pharmthera.2004.03.002.
- [11] Kyzar, Evan J., et al. “Psychedelic Drugs in Biomedicine.” Trends in Pharmacological Sciences, vol. 38, no. 11, Nov 2017, pp. 992-1005. https://doi.org/10.1016/j.tips.2017.08.003
- [12] Berrougui, Hicham, et al. “Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation.” Journal of Pharmacy and Pharmacology, Volume 58, Issue 7, July 2006, pp. 967–974, https://doi.org/10.1211/jpp.58.7.0012
- [13] Liu, Xin, et al. “Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling.” Biochemical and Biophysical Research Communications, Jul 2017, pp. 489(3):332-338. doi: 10.1016/j.bbrc.2017.05.126
- [14] Dos Santos, Rafael G., and Jaime E.C. Hallak. “Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies.” Journal of Psychoactive Drugs, vol. 49, no. 1, Dec 2016. https://doi.org/10.1080/02791072.2016.1260189
- [15] Dakic Vanja, et al.”Harmine stimulates proliferation of human neural progenitors.” PeerJ, 2016 Dec 6;4:e2727. doi: 10.7717/peerj.2727
- [16] Göckler, Nora, et al. “Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.” The FEBS Journal, vol. 276, no. 21, Nov 2009, pp. 6324-6337. https://doi.org/10.1111/j.1742-4658.2009.07346.
- [17] Kargbo, Robert B. “Selective DYRK1A Inhibitor for the Treatment of Neurodegenerative Diseases: Alzheimer, Parkinson, Huntington, and Down Syndrome.” ACS Medicinal Chemistry Letters, Jul 2020, vol. 11, no. 10, pp. 1795-1796. https://doi.org/10.1021/acsmedchemlett.0c00346
- [18] Wu, Ying-Hui, and Dick F. Swaab. “The human pineal gland and melatonin in aging and Alzheimer’s disease.” Journal of Pineal Research, Dec 2004. https://doi.org/10.1111/j.1600-079X.2004.00196.x
- [19] Dean, Jon G., et al. “Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain.” Scientific Reports, Jun 2019, 9333 https://doi.org/10.1038/s41598-019-45812-w
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