Ancestral Magi

Ameretat Neuroprotection Supplement

$50.00

Daily neuroprotection – clear the fog, support your memory, and back your cognitive future

Ingredients: Espand (Syrian rue, Peganum harmala) seed extract · grapefruit extract · pomegranate extract.

Ameretat is a precision-dosed nootropic formulated with natural extracts of Espand (Peganum harmala, or Syrian rue). This advanced supplement harnesses the power of beta-carbolines, unique neuromodulating molecules recognized for their significant contributions to neuroprotection and cognitive longevity.

Ameretat’s standardized, proprietary ingredients and unique formulation support a healthy inflammatory response in the brain — one of the systems tied to how well we age cognitively. Steady use helps clear brain fog, supports memory, and sustains daily mental clarity while easing everyday mental fatigue.

Designed as a daily foundation for anyone focused on mental performance as they age, and serious about preserving their long-term cognitive edge.

“An ounce of prevention is worth a pound of cure.” – Benjamin Franklin

  • Supports cognitive longevity & neurogenesis: Formulated with beta-carbolines like harmine, naturally occurring compounds in the body that can decrease as we age. These unique neuromodulators support long-term brain health by stimulating the proliferation of neural progenitor cells.
  • Targeted cellular support: Delivers a standardized dose of beta-carbolines, shown to act as a potent inhibitor of the DYRK1A kinase. Modulating this specific enzyme helps support neural pathways as part of a healthy-aging routine.
  • Promotes a healthy inflammatory response: The neuroprotective beta-carbolines in our extract help sustain daily mental clarity and ease mental fatigue. They achieve this by supporting a healthy, balanced inflammatory response within neuronal cells
  • 100 % natural, non-sedating, non-habit-forming – its effects compound with steady use.

Availability: 22 in stock (can be backordered)

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Product Description

Ameretat Neuroprotection Supplement is formulated with natural extracts of Espand (Peganum Harmala, or Syrian rue), a plant used by our ancestors for thousands of years in rituals. Magi’s team of PhD scientists and ethnopharmacologists formulated this microdose of Espand extracts to provide a sub-perceptual dose of natural beta-carbolines: unique neuromodulators that promote a normal, healthy response to cerebral inflammation and the release of brain growth factors. Ameretat Neuroprotection Supplement is also formulated with natural extracts of grapefruit and pomegranate, plants cultivated for over 4,000 years whose antioxidants — grapefruit flavonoids such as naringin and pomegranate polyphenols such as punicalagins and ellagic acid — help improve the bioavailability and speed of absorption of Espand-derived beta-carbolines while adding antioxidant support. In addition to its neuroprotective effects, many working professionals report taking Ameretat Neuroprotection supplements to reduce stress and improve mood, creativity, focus, and empathy.

Who Ameretat Is For

Ameretat is a daily neurogenesis supplement and brain longevity supplement — for anyone who wants to keep memory, focus, and mental clarity strong for the long run, and to support how their brain ages.
  • Adults, especially 50 and over, being proactive about long-term brain health.
  • Longevity-minded people who invest in their healthspan and want to extend that care to their mindspan — memory, learning, and clarity across the decades.
  • High-demand minds — creators, professionals, and lifelong learners — who rely on focus and recall every day.
  • Anyone who values staying mentally sharp with age and wants a natural, daily, non-habit-forming way to support it.
Ameretat is a daily wellness supplement, not a treatment for any medical condition. If you have a diagnosed condition or take prescription medication, please consult your physician before use.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Instructions

  • Take one capsule per day.
  • Do not exceed the recommended daily dose. Do not take it if you are pregnant or nursing. Consult with your physician prior to use if you have high blood pressure or a medical condition or if you take any prescription medications (including but not limited to MAO inhibitors and antidepressants).
  • Store in a cool, dry place. Keep out of reach of children and pets.

FAQ

How will I feel after taking the Ameretat?
  • Ameretat Neuroprotective Supplement is a novel nootropic formulation of Syrian rue extracts that may subtly influence certain aspects of your cognition but will not cause physiological impairment. Over time, people report feeling sharper, more open, more focused, and even more productive after regular supplementation.
How does Ameretat Neuroprotection Supplement differ from traditional microdosing?
  • Ameretat Neuroprotective Supplement is a vitamin for your brain’s neurolongevity. Many in our community report taking Ameretat for the same reasons as traditional microdosing: to provide a sub-perceptive boost to empathy, openness, and kindness, particularly kindness to self.
  • Ameretat is based on Espand-derived beta-carbolines that are fully legal in the U.S. and the Entire EU (Except France).
Should I cycle Ameretat Neuroprotection Supplement? What protocol should I follow?
  • The natural Espand-derived beta-carbolines in the Ameretat supplement do not accumulate when following the recommended dosage, and your body does not develop a tolerance for these neurotransmitters. Many people have reported that they find benefits from cycling with a break of a few days to help prolong the positive effects of this precision dose harmala formulation.
Can I take Ameretat on a daily basis?
  • The neuromodulatory effects of Ameretat Neuroprotection Supplement are immediate, sub-perceptive, non-sedative, and not habit-forming. We designed Ameretat so you can take it daily without becoming dependent.
  • Although not habit-forming, we recommend incorporating the Ameretat formula into a consistent daily intake.
Is Ameretat Neuroprotection Supplement Safe?
  • Ameretat is safe when taken as directed at the recommended dosage.
  • We designed our Ameretat from the purified natural plant extracts of Syrian rue, combined with extracts of Grapefruit and Pomegranate for bioavailability and antioxidant synergy. In addition to their anti-inflammatory and neuroprotective properties, the natural beta-carbolines extracted from Syrian rue also function as monoamine oxidase inhibitors (MAOIs) [1] that can cause an increase in blood pressure when consuming foods containing tyramine [2].
  • The levels of tyramine in food have been decreasing over time, thanks to advancements in agricultural technology and improvements in food processing and storage. Although tyramine-related hypertension affects only a small minority of the population, we recommend avoiding tyramine-rich foods when taking Ameretat.
Why is it best to take Ameretat Neuroprotection Supplement on an empty stomach?
  • The majority of our body’s neurotransmitters are in the gut, not the brain. For this reason, we recommend taking Ameretat first thing in the morning at least 20 minutes before eating, as food can interfere with neurotransmitter absorption. While this is not a requirement, the closer your stomach is to empty, the higher the bioavailability.
What is the science behind Ameretat?
  • Ameretat is formulated with Espand-derived beta-carbolines — the compounds studied in preclinical research for supporting adult neurogenesis, enhancing BDNF/TrkB signaling, calming neuro-inflammatory signaling, modulating DYRK1A, and supporting acetylcholine. See “The Science” section below for detail and citations.
How does it work?
  • Ameretat Neuroprotection Supplement contains a precise formulation of Syrian rue-derived beta-carbolines that begin to affect the central nervous system within 20 minutes of being ingested. In preclinical and mechanistic research, beta-carbolines like these have been studied for their:
    • Neuroprotective and antioxidant properties [3][4]
    • Modulation of the DYRK1A kinase, studied in preclinical research for neural-progenitor proliferation and tau biology [15]
    • Effects on inflammatory signaling pathways [6]
    • Influence on neurogenesis markers such as BDNF and neural progenitor cells in preclinical models [13][14]
    • Modulation of neuroreceptors such as serotonin, dopamine, acetylcholine, histamine, and imidazoline that are involved in perception and consciousness [7]

The Science: How Ameretat Supports Brain Longevity

Ameretat is built around beta-carbolines — a family of botanical compounds (harmine, harmaline, tetrahydroharmine) concentrated in the seeds of Espand (Peganum harmala). A growing body of neuroscience has focused on these molecules, which act through several complementary pathways studied in preclinical research:
  • Neurogenesis. Beta-carbolines stimulated adult neural stem cells to proliferate and become new neurons in cell studies [14] — a plasticity mechanism complementary to their MAO activity.
  • Neurotrophic support (BDNF/TrkB). Harmine enhanced BDNF/TrkB signaling — the pathway that helps neurons grow, connect, and survive [13].
  • A calmer neuro-inflammatory tone. Harmine suppressed inflammatory signaling, one of the processes associated with cognitive aging [12].
  • DYRK1A modulation. Harmine is a known inhibitor of the DYRK1A kinase, an axis tied to neural-progenitor proliferation and tau biology [15].
  • Acetylcholine support. Harmala alkaloids support acetylcholine — a neurotransmitter central to learning and memory [7].
Why the low dose matters: research suggests beta-carbolines are biphasic — supportive of cognition at low doses and in aging models. Ameretat is deliberately formulated as a sub-perceptive daily dose, placing it in the supportive window [13]. These findings are from preclinical and mechanistic research on the compounds; they describe how the ingredients have been studied, not medical claims about the product.

Ancestral Philosophy

Espand – Holy Plant Wisdom

In Zoroastrian tradition, Ameretat is one of the Amesha Spentas — the divine principle of immortality and enduring life, long pursued by the Magi of Ancient Iran (Persia) through contemplative inner practices. We named this formulation after her because its purpose is exactly that: the long life of the mind. Espand, also known as Syrian Rue or Peganum harmala, is the fundamental ancestral plant — burned as esfand across ancient Iran and Central Asia to purify and protect — and it is the key ingredient in Ameretat.

Syrian rue is an abundant source of beta-carbolines [8], a class of naturally occurring neuromodulatory compounds with neuroprotective properties [9]. Beta-carbolines are found naturally in a handful of plants, including Espand (P. harmala) and Banisteriopsis caapi, the ancestral Amazonian vine used in traditional ceremonial brews [10]. Thanks to modern neuroscience, we now understand the biology behind what our ancestors discovered thousands of years ago.

 

Pharmaceutical Science

Beta-Carbolines – Ancestral Secret to Neurological Health

Beta-carbolines such as harmine [11] are unique neuromodulators that have been shown to exhibit anti-inflammatory activity in neurons [12] and to support neurogenesis by increasing levels of brain-derived neurotrophic factor (BDNF) [13] and human neural progenitor cells (hNPC) [14]. They are also potent inhibitors of DYRK kinases, particularly DYRK1A [15] — a protein kinase studied extensively in preclinical research on neural-progenitor proliferation, tau biology, and cognitive aging [16].

Beta-carbolines and the aging brain

Endogenous by design. Beta-carbolines are not only plant compounds — the body makes harmine and harmaline itself. Research tracking these molecules in 550 healthy adults found that their endogenous plasma levels fall sharply with age: harmine roughly halves (about 48% lower) and harmaline drops by nearly two-thirds (about 64% lower) after age 60 [19]. Ameretat is formulated to replenish the same botanical beta-carbolines the body produces less of over time — supporting the brain through the years when its own supply is declining.


From endogenous to exogenous — closing the gap.
This is the logic behind Ameretat. If the body’s own harmine and harmaline decline with age, then supplying the same botanical beta-carbolines from an outside (exogenous) source is a natural way to help make up the difference. Rather than introducing anything foreign, a precise, sub-perceptive daily dose from Espand simply tops up a neuromodulatory system the body has drawn on its entire life — helping keep the aging brain supported through the years when its own production is winding down.

Beta-carbolines also interact with the sleep cycle via the pineal gland, the part of the brain that regulates the body’s circadian rhythm. The pineal gland regulates the sleep cycle via synthesis of melatonin from serotonin (the “happiness hormone”) [17], and is also believed to be a site of endogenous neuromodulator synthesis via alternate pathways [18].

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neuroprotection supplementAmeretat Neuroprotection Supplement
$50.00

Availability: 22 in stock (can be backordered)

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