Ameretat Neuroprotection SupplementAmeretat Neuroprotection Supplement
$12.50 – $45.00Price range: $12.50 through $45.00
Ameretat Neuroprotection Supplement is a nootropic formulated with natural extracts of Espand (Harmel, Syrian rue), an ancestral plant that has been used by our Iranian ancestors for thousands of years in rituals. Magi’s team of PhD scientists and ethnopharmacologists formulated this natural supplement from Syrian rue extracts to provide a dose of natural beta-carbolines for neuroprotection and cognitive longevity. Ameretat’s active compounds are unique neuromodulators that promote a normal and healthy response to cerebral inflammation and release of brain growth factors.
“An ounce of prevention is worth a pound of cure.” – Benjamin Franklin
- Ameretat Neuroprotection Supplement is formulated to contain a precise sub-perceptive dose of select beta-carbolines to support neuroprotection and neurogenesis.
- Ameretat contains breakthrough longevity compounds that contribute to anti-aging and cognitive longevity. Ameretat improves brain function and cognitive longevity.
- Ameretat Supplement is all-natural, non-habit-forming.
- Like traditional microdosing, Ameretat Neurogenesis Supplement may improve mood, creativity, focus, and empathy.
- Ameretat is highly recommended for daily use for individuals aged 55 years and older. They reduce the neurodegeneration significantly. However, it’s a preventative cognitive longevity formula for any age.
Product Description
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Instructions
- Take one capsule per day.
- Do not exceed the recommended daily dose. Do not take it if you are pregnant or nursing. Consult with your physician prior to use if you have high blood pressure or a medical condition or if you take any prescription medications (including but not limited to MAO inhibitors and antidepressants).
- Store in a cool, dry place. Keep out of reach of children and pets.
FAQ
How will I feel after taking the Ameretat?
- Ameretat Neuroprotective Supplement is a novel nootropic formulation of Syrian rue extracts that may have subtle influences on some aspects of your cognition but will not cause you to feel physiological impairment. Over time, people report feeling sharper, more open, more focused, and even more productive after regular supplementation.
How does Ameretat Neuroprotection Supplement differ from traditional microdosing?
- Ameretat Neuroprotective Supplement is a vitamin for your brain’s neurolongevity. Many in our community report taking Ameretat for the same reasons as traditional microdosing: to provide a sub-perceptive boost to empathy, openness, and kindness, particularly kindness to self.
- Ameretat is based on Espand-derived beta-carbolines that are fully legal in the U.S. and the Entire EU (Except France).
Should I cycle Ameretat Neuroprotection Supplement? What protocol should I follow?
- The natural Espand-derived beta-carbolines in the Ameretat supplement do not accumulate when following the recommended dosage, and your body does not develop a tolerance for these neurotransmitters. Many people have reported that they find benefits from cycling with a break of a few days to help prolong the positive effects of this precision dose harmala formulation.
Can I take Ameretat on a daily basis?
- The neuromodulatory effects of Ameretat Neuroprotection Supplement are immediate, sub-perceptive, non-sedative, and not habit-forming. We designed Ameretat so you can take it daily without becoming dependent.
- Although not habit-forming, we recommend incorporating the Ameretat formula into a consistent daily intake.
Is Ameretat Neuroprotection Supplement Safe?
- Ameretat is safe when taken as directed at the recommended dosage.
- We designed our Ameretat from the purified natural plant extracts of Syrian rue, combined with extracts of Grapefruit and Pomegranate for bioavailability and antioxidant synergy. In addition to their anti-inflammatory and neuroprotective properties, the natural beta-carbolines extracted from Syrian rue also function as monoamine oxidase inhibitors (MAOIs) [1] that can cause an increase in blood pressure when consuming foods containing tyramine [2].
- The levels of tyramine in food have been decreasing over time, thanks to advancements in agricultural technology and improvements in food processing and storage. Although tyramine-related hypertension affects only a small minority of the population, we recommend avoiding tyramine-rich foods when taking Ameretat.
Why is it best to take Ameretat Neuroprotection Supplement on an empty stomach?
- The majority of our body’s neurotransmitters are in the gut, not the brain. For this reason, we recommend taking Ameretat first thing in the morning at least 20 minutes before eating, as food can interfere with neurotransmitter absorption. While this is not a requirement, the closer your stomach is to empty, the higher the bioavailability.
How does it work?
- Ameretat Neuroprotection Supplement contains a precise formulation of Syrian rue-derived beta-carbolines that begin to affect the central nervous system within 20 minutes of being ingested. The compounds in Ameretat have been shown to:
- Inhibit neurotoxins [3] and provide neuroprotective antioxidant effects [4]
- Inhibit tumor cells [5] and promote the growth of anti-tumor cytokines [6]
- Inhibit the expression of the DYRK1a gene, which is attributed to neurodegenerative symptoms
- Inhibit inflammatory signaling and the growth of inflammatory prostaglandins [7]
- Promote neurogenesis in adults by increasing BDNF and hNPC levels
- Modulate neuroreceptors such as serotonin, dopamine, acetylcholine, histamine, and imidazoline that are involved in perception and consciousness [8]
Ancestral Philosophy
Espand – Holy Plant Wisdom
Ameretat is the divine concept of immortality pursued ritually by the Zoroastrians of Ancient Iran (Persia) through spiritual inner journey practices. Espand, also known as Syrian Rue or Peganum Harmala, is the fundamental ancestral plant consumed and burned as incense in these ancestral traditions and is the key ingredient in Ameretat Neurogenesis Supplement.
Syrian rue is an abundant source of beta-carbolines [9], a class of naturally occurring organic compounds with psychoactive and neuroprotective properties [10]. Beta-carbolines are found naturally in a few plants, including Espand (P. Harmala) and Yage (Banisteriopsis Caapi), the ancestral Amazonian plant that is the main ingredient in the psychedelic brew Ayahuasca [11]. Thanks to modern science, we now understand the neurochemistry behind what our ancestors discovered thousands of years ago.
Pharmaceutical Science
Beta-Carbolines – Ancestral Secret to Neurological Health
Beta-carbolines such as harmine [12] are unique neuromodulators that have been shown to exhibit anti-inflammatory activity in neurons [13] and promote neurogenesis by increasing levels of brain-derived neurotrophic factor (BDNF) [14] and human neural progenitor cells (hNPC) [15]. They are also potent inhibitors of DYRK genes, particularly DYRK1a [16], the protein kinase implicated in the pathology of numerous neurodegenerative disorders [17].
Beta-carbolines also interact with the sleep cycle via the pineal gland, the part of the brain that regulates the body’s circadian rhythm. The pineal gland regulates the sleep cycle via synthesis of melatonin from serotonin (the “happiness hormone”) [18], and is also believed to produce both beta-carbolines and the psychedelic compound DMT (the “spirit molecule”) via alternate pathways [19].
References
- [1] Mckenna, Dennis J., et al. “Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of Ayahuasca.” Journal of Ethnopharmacology, vol. 10, no. 2, Apr 1984, pp 195-223. https://doi.org/10.1016/0378-8741(84)90003-5
- [2] McCabe, Beverly J. “Dietary tyramine and other pressor amines in MAOI regimens: A review.” Journal of the American Dietetic Association, vol.86, no. 8, Aug 1986, pp. 1059-1064. https://doi.org/10.1016/S0002-8223(21)04074-8
- [3] Herraiz, Tomás, and Hugo Guillén. “Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors.” Food and Chemical Toxicology, 2011 Aug;49(8):1773-81. doi: 10.1016/j.fct.2011.04.026.
- [4] Samoylenko, Volodymyr, et al. “Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson’s disease.” Journal of Ethnopharmacology, vol. 127, no. 2, Feb 2010, pp. 357-367. https://doi.org/10.1016/j.jep.2009.10.030
- [5] Bikadar, SM, et al. “Cerebroprotective effect of isolated harmine alkaloids extracts of seeds of Peganum harmala L. on sodium nitrite-induced hypoxia and ethanol-induced neurodegeneration in young mice.” Pakistan Journal of Biological Sciences, 01 Dec 2013, 16(23):1687-1697. DOI: 10.3923/pjbs.2013.1687.1697
- [6] Hamsa, T.P., and Girija Kuttan. “Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro.” European Journal of Pharmacology, 2010 Dec 15;649(1-3):64-73. doi: 10.1016/j.ejphar.2010.09.010.
- [7] Moloudizargari, Milad, et al. “Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids.” Pharmacognosy Reviews, 2013 Jul-Dec; 7(14): 199–212. doi: 10.4103/0973-7847.120524
- [8] Airaksinen, MM, and Kari I. “Beta-carbolines, psychoactive compounds in the mammalian body. Part I: Occurrence, origin and metabolism.” Medical Biology. 1981 Feb;59(1):21-34. PMID: 7022042.
- [9] Frost, Danielle, et al. “β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer’s Disease-Related Sites.” PLoS ONE 6(5): e19264, May 2011. https://doi.org/10.1371/journal.pone.0019264
- [10] Dennis J McKenna,“Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges.” Pharmacology & Therapeutics, Volume 102, Issue 2, 2004, pp. 111-129. https://doi.org/10.1016/j.pharmthera.2004.03.002.
- [11] Kyzar, Evan J., et al. “Psychedelic Drugs in Biomedicine.” Trends in Pharmacological Sciences, vol. 38, no. 11, Nov 2017, pp. 992-1005. https://doi.org/10.1016/j.tips.2017.08.003
- [12] Berrougui, Hicham, et al. “Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation.” Journal of Pharmacy and Pharmacology, Volume 58, Issue 7, July 2006, pp. 967–974, https://doi.org/10.1211/jpp.58.7.0012
- [13] Liu, Xin, et al. “Harmine is an inflammatory inhibitor through the suppression of NF-κB signaling.” Biochemical and Biophysical Research Communications, Jul 2017, pp. 489(3):332-338. doi: 10.1016/j.bbrc.2017.05.126
- [14] Dos Santos, Rafael G., and Jaime E.C. Hallak. “Effects of the Natural β-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies.” Journal of Psychoactive Drugs, vol. 49, no. 1, Dec 2016. https://doi.org/10.1080/02791072.2016.1260189
- [15] Dakic Vanja, et al.”Harmine stimulates proliferation of human neural progenitors.” PeerJ, 2016 Dec 6;4:e2727. doi: 10.7717/peerj.2727
- [16] Göckler, Nora, et al. “Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.” The FEBS Journal, vol. 276, no. 21, Nov 2009, pp. 6324-6337. https://doi.org/10.1111/j.1742-4658.2009.07346.
- [17] Kargbo, Robert B. “Selective DYRK1A Inhibitor for the Treatment of Neurodegenerative Diseases: Alzheimer, Parkinson, Huntington, and Down Syndrome.” ACS Medicinal Chemistry Letters, Jul 2020, vol. 11, no. 10, pp. 1795-1796. https://doi.org/10.1021/acsmedchemlett.0c00346
- [18] Wu, Ying-Hui, and Dick F. Swaab. “The human pineal gland and melatonin in aging and Alzheimer’s disease.” Journal of Pineal Research, Dec 2004. https://doi.org/10.1111/j.1600-079X.2004.00196.x
- [19] Dean, Jon G., et al. “Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain.” Scientific Reports, Jun 2019, 9333 https://doi.org/10.1038/s41598-019-45812-w
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