Ameretat Neuroprotection SupplementAvailability: 22 in stock (can be backordered)
$50.00
Daily neuroprotection – clear the fog, support your memory, and back your cognitive future
Ingredients: Espand (Syrian rue, Peganum harmala) seed extract · grapefruit extract · pomegranate extract.
Ameretat is a precision-dosed nootropic formulated with natural extracts of Espand (Peganum harmala, or Syrian rue). This advanced supplement harnesses the power of beta-carbolines, unique neuromodulating molecules recognized for their significant contributions to neuroprotection and cognitive longevity.
Ameretat’s standardized, proprietary ingredients and unique formulation support a healthy inflammatory response in the brain — one of the systems tied to how well we age cognitively. Steady use helps clear brain fog, supports memory, and sustains daily mental clarity while easing everyday mental fatigue.
Designed as a daily foundation for anyone focused on mental performance as they age, and serious about preserving their long-term cognitive edge.
“An ounce of prevention is worth a pound of cure.” – Benjamin Franklin
Availability: 22 in stock (can be backordered)
In Zoroastrian tradition, Ameretat is one of the Amesha Spentas — the divine principle of immortality and enduring life, long pursued by the Magi of Ancient Iran (Persia) through contemplative inner practices. We named this formulation after her because its purpose is exactly that: the long life of the mind. Espand, also known as Syrian Rue or Peganum harmala, is the fundamental ancestral plant — burned as esfand across ancient Iran and Central Asia to purify and protect — and it is the key ingredient in Ameretat.
Syrian rue is an abundant source of beta-carbolines [8], a class of naturally occurring neuromodulatory compounds with neuroprotective properties [9]. Beta-carbolines are found naturally in a handful of plants, including Espand (P. harmala) and Banisteriopsis caapi, the ancestral Amazonian vine used in traditional ceremonial brews [10]. Thanks to modern neuroscience, we now understand the biology behind what our ancestors discovered thousands of years ago.
Beta-carbolines such as harmine [11] are unique neuromodulators that have been shown to exhibit anti-inflammatory activity in neurons [12] and to support neurogenesis by increasing levels of brain-derived neurotrophic factor (BDNF) [13] and human neural progenitor cells (hNPC) [14]. They are also potent inhibitors of DYRK kinases, particularly DYRK1A [15] — a protein kinase studied extensively in preclinical research on neural-progenitor proliferation, tau biology, and cognitive aging [16].

Endogenous by design. Beta-carbolines are not only plant compounds — the body makes harmine and harmaline itself. Research tracking these molecules in 550 healthy adults found that their endogenous plasma levels fall sharply with age: harmine roughly halves (about 48% lower) and harmaline drops by nearly two-thirds (about 64% lower) after age 60 [19]. Ameretat is formulated to replenish the same botanical beta-carbolines the body produces less of over time — supporting the brain through the years when its own supply is declining.

From endogenous to exogenous — closing the gap. This is the logic behind Ameretat. If the body’s own harmine and harmaline decline with age, then supplying the same botanical beta-carbolines from an outside (exogenous) source is a natural way to help make up the difference. Rather than introducing anything foreign, a precise, sub-perceptive daily dose from Espand simply tops up a neuromodulatory system the body has drawn on its entire life — helping keep the aging brain supported through the years when its own production is winding down.
Beta-carbolines also interact with the sleep cycle via the pineal gland, the part of the brain that regulates the body’s circadian rhythm. The pineal gland regulates the sleep cycle via synthesis of melatonin from serotonin (the “happiness hormone”) [17], and is also believed to be a site of endogenous neuromodulator synthesis via alternate pathways [18].


Ameretat Neuroprotection SupplementAvailability: 22 in stock (can be backordered)